HBV and HCV infection in kidney transplant recipients

The risk of HBV and HCV liver infection in kidney graft recipients was evaluated in 35 patients. All were tested for anti-HBc, HBsAg, HBeAg, anti-HBs, Anti-HBe, anti-HCV (c-100-3 and c-100-3, c-22, 33-c), anti-HDV and anti-HIV by ELISA, and for HBV-DNA by hybridization. Liver biopsy, immunostaining for HBcAg and Knodell’s hepatic inflammatory index were performed in 18. Mean time elapsing form transplant to inclusion was 20.7 months (range 1-108). HBsAg was the only marker searched for prior to transplant. Twenty six (74.2

) HBsAg+, (3 HBeAg+ and 3 anti-HBe+), 7 (20

) anti-HBs+ and 3 (8.5

) isolated anti-HBc. Anti-HCV (C-100-3) was positive in 9/32 (28.1

), while 2nd. generation anti-HCV was positive in 20/35 (57.1

) cases. No false positives for 1st. generation test were found. Both anti-HDV and anti-HIV were negative in all the sample. Raised aminotransferases were present in 13/30 (43.3

), 7 in anti-HCV+, one in HBsAg+ and 3 in HBsAg+/HCV+ cases, but normal in 17/30 (56.6

). History of Transfusion and Hemodialysis time showed no significant differences between anti-HCV+ and anti-HCV negative cases. Biopsy disclosed 10 chronic persistent hepatitis (CPH), one chronic active hepatitis (CAH) with cirrhosis, one inactive cirrhosis (Ci) 4 minimal lesions (MHL) and 2 normal. Seven CPH, 3 MHL. one normal and both cirrhosis cases proved anti-HCV+. HBsAg was positive in the single CAH, in 2 CPH and in one MHL.(ABSTRACT TRUNCATED AT 250 WORDS)

Características epidemiológicas de la displasia congénita de caderas en una población chilena / Epidemiologic characteristics of congenital hip dysplasia in a chilean population

Se presentan los resultados de un estudio retrospectivo de 97 casos de displasia congénita de caderas y 100 controles pareados por sexo y peso de nacimiento. Se encontró una relación sexo femenino: sexo masculino 6,5:1, predominio del compromiso bilateral (68%) y diferencias estadísticamente significativas entre casos y controles en los antecedentes familiares de displasia y presentación podálica completa. En 23% de los casos no hubo sospecha clínica previa al diagnóstico radiológico. Los autores plantean la necesidad de aplicar programas de tamizaje de mayor sensibilidad empleando estudios radiológicos y ultrasonográficos, en particular en niños con antecedentes de factores de riesgo